Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins
This report describes the discovery and initial characterization of the first positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5). Functional HTS, identified VU0119498, which displayed micromolar potencies for poten
Bridges, Thomas M.,Marlo, Joy E.,Niswender, Colleen M.,Jones, Carrie K.,Jadhav, Satyawan B.,Gentry, Patrick R.,Plumley, Hyekyung C.,Weaver, C. David,Conn, P. Jeffrey,Lindsley, Craig W.
supporting information; experimental part
p. 3445 - 3448
(2010/04/02)
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