SYNTHESIS OF OPTICALLY ACTIVE RADIO-LABELED REVERSE TRANSCRIPTASE INHIBITORS
Disclosed herein are isotopically labeled reverse transcriptase inhibitors, including compounds according to the formula (I) wherein R1 and R2 independently are selected from H, lower alkyl, aralkyl, acyl and Z1 and Z
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Enantiomeric radiochemical synthesis of R and S (1-(6-amino-9H-purin-9-yl)- 3-fluoropropan-2-yloxy)methylphosphonic acid (FPMPA)
Therapy for human immunodeficiency virus (HIV)-infected patients requires chronic multidrug administration. The eventual failure of therapy in some patients has brought into question the tissue concentration of the drugs. With an appropriately radiolabele