- PROCESS FOR PREPARATION OF NOVEL ANDROGEN RECEPTOR ANTAGONIST
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A process for the preparation of a novel androgen receptor antagonist is provided, comprising essentially conducting cyclization reaction of a compound of formula V to obtain a compound of formula VI. This method has the advantages of easily obtainable starting material, high atomic utilization rate, mild reaction conditions, and simply post-treatment. In addition, ODM-201 and its single isomers can be synthesized directionally by controlling the stereochemistry of starting material, with the advantages of simple and controllable process and suitability for industrial production.
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Page/Page column 20; 28
(2018/07/05)
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- 3-Acyltetramic Acid Antibiotics. 3. An Approach to the Synthesis of Bu-2313
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An approach to the synthesis of the bicyclononane portion of the 3-acyltetramic acid antibiotic Bu-2313 is presented.The highly unstable α-keto aldehyde obtained by Swern oxidation of the diol 23 was allowed to condense with the unreactive α-keto phosphor
- Ireland, Robert E.,Wardle, Robert B.
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p. 1780 - 1789
(2007/10/02)
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