Palladium-Catalyzed Carbonylation of (Hetero)Aryl, Alkenyl and Allyl Halides by Means of N-Hydroxysuccinimidyl Formate as CO Surrogate
An efficient Pd-catalyzed carbonylation protocol is described for the coupling of a large panel of aryl, heteroaryl, benzyl, vinyl and allyl halides 2 with the unusual N-hydroxysuccinimidyl (NHS) formate 1 as a CO surrogate to afford the corresponding valuable NHS esters 3. High conversion to the coupling products was achieved with up to 98% yield by means of Pd(OAc)2/Xantphos catalyst system.
Barré, Ana?s,T?nta?, Mihaela-Liliana,Alix, Florent,Gembus, Vincent,Papamica?l, Cyril,Levacher, Vincent
p. 6537 - 6544
(2015/10/05)
Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase
A series of quinoxaline inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and optimisation of the series was performed on the basis of this structure. Future directions for development of the
Porter, John,Lumb, Simon,Lecomte, Fabien,Reuberson, James,Foley, Anne,Calmiano, Mark,le Riche, Kelly,Edwards, Helen,Delgado, Jean,Franklin, Richard J.,Gascon-Simorte, Jose M.,Maloney, Alison,Meier, Christoph,Batchelor, Mark
p. 397 - 400
(2011/03/17)
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