- Synthesis of aza mono, bi and tricyclic compounds. Evaluation of their anti MDR activity
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Anti MDR activity of a series of acridine, pyridoquinoline, quinoline and pyridine analogous amines was evaluated. Interesting activity is displayed by tricyclic compounds. Besides ring size, influence of the side chain was studied.
- Gallo, Sandrine,Atifi, Siham,Mahamoud, Abdallah,Santelli-Rouvier, Christiane,Wolfart, Krisztina,Molnar, Jozsef,Barbe, Jacques
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- Assembly of Primary (Hetero)Arylamines via CuI/Oxalic Diamide-Catalyzed Coupling of Aryl Chlorides and Ammonia
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A general and practical catalytic system for aryl amination of aryl chlorides with aqueous or gaseous ammonia has been developed, with CuI as the catalyst and bisaryl oxalic diamides as the ligands. The reaction proceeds at 105-120°C to provide a diverse set of primary (hetero)aryl amines in high yields with various functional groups.
- Fan, Mengyang,Zhou, Wei,Jiang, Yongwen,Ma, Dawei
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supporting information
p. 5934 - 5937
(2015/12/11)
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- The interaction between resistance modifiers such as pyrido[3,2-g] quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA
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Various resistance mechanisms such as complex formation with DNA, tRNA and MDR1 p-glycoprotein were modified in bacteria and cancer cells in presence of pregnane, pyridoquinoline, and aza-oxafluorene derivatives. Interaction between the compounds, plasmid
- Sharples, Derek,Spengler, Gabriella,Molnár, Joseph,Antal, Zsuzsanna,Molnár, Annamária,Kiss, János T.,Szabó, József A.,Hilgeroth, Andreas,Gallo, Sandrine,Mahamoud, Abdallah,Barbe, Jacques
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p. 195 - 202
(2007/10/03)
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- GUANIDINYLAMINO HETEROCYCLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS
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This invention involves compounds having the structure (I) as described in the claims, and enantiomers,optical isomers, stereoisomers, diastereomers, tautomers, addition salts, biohydrolyzable amides and esters thereof, as well as pharmaceutical compositi
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- Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists
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This invention involves compounds having the following structure: as described in the Claims; and enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts, biohydrolyzable amides and esters thereof, as well as pharmaceutical compositions comprising such novel compounds. The invention also relates to the use of such compounds for preventing or treating disorders modulated by alpha-2 adrenoceptors.
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- 7-(2-IMIDAZOLINYLAMINO)QUINOLINE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS
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This invention involves involves the use of compounds having the following structure: STR1 wherein: (a) R is unsubstituted C 1-C. sub.3 alkanyl or alkenyl; and(b) R' is selected from hydrogen; unsubstituted C 1-C 3 alkanyl or alkenyl; unsubstituted
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- 7-(2-IMIDAZOLINYLAMINO)QUINOLINE COMPOUNDS USEFUL AS ALPHA-2-ADRENOCEPTOR AGONISTS
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The subject invention involves methods of treating nasal congestion comprising administration, to a human or lower animal in need of such treatment of a safe and effective amount of a compound having the following structure: STR1 wherein: (a) R is unsubst
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- 7-(2-IMIDAZOLNYLAMINO) QUINOLINE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS
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The subject invention involves methods of treating nasal congestion comprising administration, to a human or lower animal in need of such treatment of a safe and effective amount of a compound having the following structure: STR1 wherein: (a) R is unsubst
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- Syntheses of Novel Quinolone-Chemotherapeutics, I: Pyridoquinolines and Pyridophenanthrolines as Derivatives of "lin-benzo-Nalidixic Acid"
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Expansion of nalidixic acid (NA) has been accomplished by linear insertion of a benzo-ring between the two pyrido moieties.The resulting compounds exhibit antibacterial activity comparable to NA and are highly fluorescent.The regioselective hydrogenation of 1,7-phenanthrolines was studied. - Keywords: lin-Benzo-analogs; Quinolones; Pyridoquinoline; Pyridophenanthroline; Pyridophenanthroline; Regioselective hydrogenation of phenanthrolines; Fluorescence
- Jordis, U.,Sauter, F.,Rudolf, M.,Cai, Gan
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p. 761 - 780
(2007/10/02)
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