Structure-activity relationships of antimalarial indoloquinolines
Structure-activity relationships have been ascertained and chemical metodology developed for a series of antimalarial 3-chloroindoloquinoline-5-oxides.The basic side chain as well as the ring N-oxide are critical for antimalarial activity as is a bromine or chlorine in position 3.Substitution at positions 7,8,9,10 in not essential, although the most potent analog in our studies was the 8-nitro compound 4vv. indoloquinolines / antimalarial agents
Werbel, L. M.,Kesten, S. J.,Turner, W. R.
p. 837 - 852
(2007/10/02)
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