cas 116986-09-5, METHYL 3-BROMOMETHYLPYRIDINE-2-CARBOXYLATE | Articles data ｜lookchem

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116986-09-5

Articles about 116986-09-5Total 4 be found

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Modular Route to Azaindanes
A convergent radical based route to azaindanes is described, relying on the degenerative addition transfer of various substituted S-(pyridylmethyl)-O-ethyl dithiocarbonates (xanthates) to functional alkenes followed by radical cyclization onto the pyridine ring activated by protonation with trifluoroacetic acid. In one case, a richly decorated cyclohepta[b]pyridine could be assembled swiftly by allowing the first adduct to N-phenylmaleimide to undergo addition to N-allylphthalimide prior to cyclization.
Huang, Qi,Zard, Samir Z.
supporting information
p. 3895 - 3898
(2017/07/26)

PRMT5 INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof:wherein Y1 is of formula (?) or formula (y):Ring Y is a 5- to 6-membered heteroaryl ring; and V4, V5, Rx, x, y, and n are as defined herein. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.
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(2016/04/20)

COMPOUNDS FOR TREATING VIRAL INFECTIONS
The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.
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Page/Page column 82

(2008/12/08)

Synthesis of New Thiopyranopyridines
The synthesis of 5H-thiopyranopyridines, 8H-thiopyranopyridines, 1H-thiopyranopyridines and 1H-thiopyranopyridines from methyl pyridine esters 5-8 and nitriles 17-20 by simple photobromination, followed by reaction of the intermediate bromomethyl derivative with methyl thioglycolate and subsequent base induced cyclisation of the latter are reported.
Dunn, A. D.
p. 557 - 562
(2007/10/02)

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Chemical Properties

Boiling Point: 338.6°Cat760mmHg
Flash Point:158.6°C
Density: 1.533g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Vapor Pressure: 9.74E-05mmHg at 25°C
Refractive Index: 1.563
PKA: 0.57±0.10(Predicted)
PSA: 39.19000
LogP: 1.76310

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