- Green preparation method of 2,2-bis(4-aminophenyl)hexafluoropropane
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The invention relates to the field of fine organic synthesis, in particular to a green preparation method of 2,2-bis(4-aminophenyl)hexafluoropropane. The green preparation method comprises the following steps: (a) carrying out oxidation reaction on 2,2-bis(4-methylphenyl)hexafluoropropane and oxygen in a perfluorinated compound solvent, and conducting separating to obtain 2,2-bis (4-carboxyphenyl)hexafluoropropane; (b) carrying out a reflux reaction on the compound obtained in the step (a) and ammonia gas in an organic solvent to obtain ammonium salt of 2,2-bis(4-carboxylphenyl)hexafluoropropane; (c) mixing the compound obtained in the step (b) with an organic solvent, carrying out heating, and raising a temperature for dehydrating to obtain 2,2-bis(4-formamidophenyl)hexafluoropropane; and (d) carrying out a Hofmann degradation reaction on the compound obtained in the step (c) and sodium hypochlorite in a hydrofluoroether solvent, and carrying out purifying to obtain the 2,2-bis(4-aminophenyl)hexafluoropropane. According to the invention, a selected oxidizing agent is economical and green, and the oxidizing solvent is non-combustible and non-explosive; and a hydrofluoroether solvent is selected for the Hofmann reaction, so high-COD wastewater is reduced, and industrial production is facilitated.
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Paragraph 0037-0040; 0048-0081
(2021/11/10)
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- Novel synthetic method for 2,2-bis(4-aminophenyl)hexafluoropropane
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The invention relates to a novel synthetic method for 2,2-bis(4-aminophenyl)hexafluoropropane. The novel synthetic method is mainly to solve problems like high hazards, large product separation and purification difficulties, expensive raw materials and harsh reaction conditions in a traditional synthetic method. The method comprises the following steps: with 2,2-bis(4-methylphenyl)hexafluoropropane as a raw material, oxidizing the 2,2-bis(4-methylphenyl)hexafluoropropane into 2,2-bis(4-carboxylphenyl)hexafluoropropane through chromium trioxide, then carrying out an acyl chlorination reaction,introducing ammonia gas, carrying out an amidation reaction so as to obtain 2,2-bis(4-formamidophenyl)hexafluoropropane, and carrying out a Hoffman reaction in a sodium hypochlorite solution so as toobtain a target product. The method provided by the invention has the advantages of cheap and easily-available raw materials, mild reaction conditions, easy industrialization, etc.
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Paragraph 0021; 0023; 0025; 0026; 0027; 0038-0041
(2018/09/08)
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