The Synthesis of (R)-(-) and (S)-(+)-Hydroxysaclofen
2-(4-Chlorophenyl)-3-hydroxypropene has been separately converted to both enantiomers of its epoxide.The epoxides were converted to (R)-(-) and (S)-(+)-hydroxysaclofen.Only the latter showed activity as a specific GABAB antagonist.
Prager, Rolf H.,Schafer, Karl,Hamon, David P. G.,Massy-Westropp, Ralph A.
p. 11465 - 11472
(2007/10/02)
Potential GabaB Receptor Antagonists. V. The Application of Radical Additions to Styrenes to Produce 2-Hydroxysaclofen
3-Amino-2-(4-chlorophenyl)-2-hydroxypropanesulfonic acid (2-hydroxysaclofen), and its 2-phenyl analogue have been synthesized by three methods.Two involve the oxygen-catalysed free radical addition of bisulfite to the corresponding 3-aminopropene or 3-pht
Abbenante, Giovanni,Prager, Rolf H.
p. 1791 - 1800
(2007/10/02)
Synthesis of 3-Amino-2-(4-chlorophenyl)propanesulfonic Acid (Saclofen) and 3-Amino-2-(4-chlorophenyl)-2-hydroxypropanesulfonic Acid (Hydroxysaclofen)
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Abbenante, Giovanni,Prager, Rolf H.
p. 213 - 214
(2007/10/02)
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