- NITROGENOUS FUSED HETEROAROMATIC RING DERIVATIVE
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The invention provides a compound or its pharmaceutically-acceptable salt of formula (I): wherein A1 is a hydrogen, etc.; j and k are 0 or 1; is a double bond, etc.; is a double bond, etc.; one of W1 and W2 is E-O-W, etc., and the other is a hydrogen atom, etc.; E is a divalent group derived from a benzene ring, etc., by removing two hydrogen atoms therefrom; W is a group of formula (II-1): which has a histamine-H3 receptor antagonistic effect or a histamine-H3 receptor inverse-agonistic effect and is useful for prevention or remedy of metabolic system diseases, circulatory system diseases or nervous system diseases.
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Page/Page column 43-44
(2010/11/24)
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- A New and Improved Synthesis of 6-Aryl-1,2,4-triazolopyridazines
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A new and improved synthesis of 6-aryl-1,2,4-triazolopyridazines is described.This methodology provides the title compounds under mild conditions and in high yields.The first step comprises the condensation of an aryl methyl ketone with a 4-amino-1
- Lieberman, Daniel F.,Albright, J. Donald
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p. 827 - 830
(2007/10/02)
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