- Preparation method, preparation device and intermediate of 4 -chlorophthalic anhydride
-
The invention discloses a preparation method of 4 -chlorophthalic anhydride, a preparation device and an intermediate. The preparation method comprises the following steps: 2, 3 - dichloro maleic anhydride and 2 - chlorine -1, 3 - butadiene takes place cyclization reaction to obtain 1, 2 and 4 - trichloroacetic anhydride. Reaction of the 1, 2 and 4 - trichloroalternative dihydrophthalic anhydride in the removal HCl results in 4 -chlorophthalic anhydride. The chlorination reaction of maleic anhydride and thionyl chloride under the conditions of pyridine catalysts gives the 2, 3 -dichloromaleic anhydride. By adopting 2, 3 -dichloromaleic anhydride and 2 - chlorine -1, 3 - butadiene takes place D-A cyclization reaction, HCl-chlorophthalic anhydride is synthesized with high selectivity, and the 4 - 4 -chlorophthalic anhydride process disclosed by the invention realizes continuous production.
- -
-
Paragraph 0084; 0100-0108; 0115-0117; 0124-0126; 0133; ...
(2021/10/27)
-
- A double-(mild imide) preparation method (by machine translation)
-
The invention relates to a double-(mild imide) of the preparation method, the phthalic anhydride is dissolved in water, into the chlorine gas, heating the reaction system to 25 - 80 °C, sustained reaction 8 - 12 hours, met for preparing double-(mild imide) the technological requirements of mild phthalic anhydride; the prepared mild phthalic anhydride and diamine compound in presence of solvent, in the 40 - 300 °C lower, vacuum to - 0.02 - - 0.08 mpa reaction 8 - 16 hours, the reaction after the end of the, is filtered by the filter cake, the filter cake washing in boiling water, filtering to obtain the double-(mild imide). The invention producing polyimide precursor double (mild imide) of the method is simple and convenient, the reaction is carried out under negative pressure, the safety is high, using only the solvent, without using a catalyst and a dehydrating agent, and after treatment is simple, and is suitable for industrial production, the production cost is low, the product quality is good. (by machine translation)
- -
-
Paragraph 0041; 0042
(2018/07/07)
-
- Pd-Catalyzed Decarbonylative Cross-Couplings of Aroyl Chlorides
-
This report describes a method for Pd-catalyzed decarbonylative cross-coupling that enables the conversion of carboxylic acid derivatives to biaryls, aryl amines, aryl ethers, aryl sulfides, aryl boronate esters, and trifluoromethylated arenes. The success of this transformation leverages the Pd0/Brettphos-catalyzed decarbonylative chlorination of aroyl chlorides, which can then participate in diverse cross-coupling reactions in situ using the same Pd catalyst.
- Malapit, Christian A.,Ichiishi, Naoko,Sanford, Melanie S.
-
supporting information
p. 4142 - 4145
(2017/08/15)
-
- PROCESS FOR THE PREPARATION OF ORGANIC HALIDES
-
The present invention provides a halo-de-carboxylation process for the preparation of organic chlorides, organic bromides and mixtures thereof, from their corresponding carboxylic acids, using a chlorinating agent selected from trichloroisocyanuric acid (TCCA), dichloroisocyanuric acid (DCCA), or combination thereof, and a brominating agent.
- -
-
Paragraph 00146
(2017/08/01)
-
- ALLOSTERIC PROTEIN KINASE MODULATORS
-
The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.
- -
-
Page/Page column 45
(2012/03/10)
-
- Dual fluorescent N-Aryl-2,3-naphthalimides: Applications in ratiometric DNA detection and white organic light-emitting devices
-
A ten element matrix of 5- and 6-substituted-(2,3)-naphthalimides was prepared for the appropriate placement of substituents necessary to promote dual fluorescence (DF). As prescribed by our balanced seesaw photophysical model this matrix yielded nine new DF dyes out of a possible ten compounds. From this set of nine DF dyes, 4-fluoronaphthalic amide (37) was selected as a probe for ratiometric detection of DNA and demonstration of panchromatic emission.
- Nandhikonda, Premchendar,Heagy, Michael D.
-
supporting information; experimental part
p. 4796 - 4799
(2011/01/03)
-
- ALLOSTERIC PROTEIN KINASE MODULATORS
-
The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.
- -
-
Page/Page column 93-94
(2010/04/30)
-
- Sarcosine based indandione hGlyT1 inhibitors
-
A series of sarcosine based indandione hGlyT1 inhibitors has been developed. Optimization of substitution around the indandione and sarcosine moieties has led to highly potent inhibitors at hGlyT1, which show selectivity over a number of other receptors.
- Thomson, Christopher G.,Duncan, Karen,Fletcher, Stephen R.,Huscroft, Ian T.,Pillai, Gopalan,Raubo, Piotr,Smith, Alison J.,Stead, Darren
-
p. 1388 - 1391
(2007/10/03)
-
- Method of making halophthalic acids and halophthalic anhydrides
-
A method of preparing a halophthalic acid is disclosed which comprises the steps of contacting in a liquid phase reaction mixture at least one halogen-substituted ortho-xylene with oxygen and acetic acid at a temperature in a range between about 120° C. and about 220° C. in the presence of a catalyst system yielding a product mixture comprising less than 10 percent halogen-substituted ortho-xylene starting material, a halophthalic acid product, and less than about 10,000 ppm halobenzoic acid and less than about 1000 ppm halophthalide by-products based on a total amount of halophthalic acid present in the product mixture. In addition a method for the preparation of halophthalic anhydride is also disclosed.
- -
-
Page/Page column 9
(2008/06/13)
-
- PREPARATION OF SUBSTITUTED PHTHALIC ANHYDRIDE, ESPECIALLY 4-CHLOROPHTALIC ANHYDRIDE
-
A method for the synthesis of substituted phthalic anhydrides (IV) wherein R' is a halogen, aromatic or aliphatic group comprising 1-18 carbons, hydrogen or nitro group is the transimidation between a substituted N-alkyl phthalimide (V) wherein R is an alkyl having from 1 to 18 carbons, and a substituted tetrahydrophthalic anhydride (VI): The by product of this reaction, a substituted N-alkyl tetrahydrophthalimide (VII), may be converted by aromatization to the substituted N-alkyl phthalimide (V).
- -
-
-
- Method for oxidation of xylene derivatives
-
Xylene derivatives, such as chloro-ortho-xylene, are oxidized in the absence of solvent or added promoter in the presence of at least one metal catalyst. The primary products are chlorophthalic anhydride and chlorotoluic acid.
- -
-
-
- Inhibitors of microsomal triglyceride transfer protein and method
-
Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure STR1 wherein R1 to R7, Q, X and Y are as defined herein.
- -
-
-
- Synthesis of 4-substituted phthalic anhydrides
-
Disclosed is a method of making a 4-substituted phthalic anhydride. A halomaleic (including halofumaric anhydride (or the acid or ester thereof) is made by the reaction of-maleic anhydride with chlorine or bromine. The halomaleic anhydride is reacted with a conjugated diene to form a first cycloadduct having the formula STR1 The first cycloadduct is heated to eliminate HX and produce a second cycloadduct having the formula STR2 The second cyclo adduct is dehydrogenated to produce a 4substituted phthalic anhydride which has the formula STR3 where R1, R2, and R4 are preferably H and R3 is preferably Cl or F.
- -
-
-
- Process for the preparation of halophthalic anhydrides
-
A process for the preparation of a halophthalic anhydride, such as chlorophthalic anhydride, comprising the liquid phase reaction of bromine with a halogen substituted hexa- or tetra-hydrophthalic anhydride to produce halophthalic anhydride and gaseous HBr, and reacting the gaseous HBr with chlorine to regenerate bromine.
- -
-
-
- Method for the preparation of halophthalic anhydrides
-
Halophthalic anhydrides are prepared by reaction of chlorine with a saturated or partially saturated halophthalic anhydride at a temperature of 200° to 500° Celsius.
- -
-
-
- Process for the preparation of halophthalic anhydrides
-
Halophthalic anhydrides are prepared by the liquid phase reaction of a brominating agent with halogen substituted hexa- or tetra-hydrophthalic anhydrides.
- -
-
-
- Preparation of halogenated phthalic anhydrides
-
A process for the aromatization of 4-chlorotetrahydrophthalic anhydride and 4,5-dichlorotetrahydrophthalic anhydride which comprises heating a solution of either substance in the presence of activated carbon and in the partial absence of air.
- -
-
-
- Preparation of halogen substituted phthalic anhydride
-
A process for the preparation of halogen substituted phthalic anhydrides of the formula: STR1 wherein x is a halogen, by the reaction of a halogen substituted tetrahydrophthalic phthalic anhydride of the formula STR2 or a geminal dihalogen substituted hexahydrophthalic anhydride of the formula STR3 in a vapor or liquid phase while mixed with an air flow and an activated carbon catalyst at an elevated temperature.
- -
-
-
- Light stabilizing flame retardants
-
This invention provides novel hindered amine light stabilizers with flame retardant properties. The compounds of this invention protect polymeric compositions against the degradative effects of heat and light and simultaneously improve the flammability rating of the polymeric composition, while also contributing antioxidant and metal deactivation properties to the polymeric compositions. The compositions of this invention are prepared by reacting halogenated flame retardant containing a cyclic anhydride group with hindered amine light stabilizers containing primary amino or reactive hydrazido functional groups. The preparation of the novel compositions may be carried out in inert solvents or in inert polymeric compositions in a melt blending step.
- -
-
-
- Pyrophtalones VII. Synthese et activite anti-inflammatoire de (pyridinyl-4)-2 indanediones-1,3 substituees sur le noyau benzenique et/ou sur l'heterocycle
-
Pyrophthalones VII.Synthesis and anti-inflammatory activity of 2-(4-pyridinyl)indane-1,3-diones diversely substituted on the benzene ring.Access routes to 2-(1,4-dihydro 4-pyridinylidene) indane-1,3-diones diversely substituted on the benzene ring are studied.The regiospecific attack of these β diketoenamines by alkyl iodides leads to N-substituted compounds.These derivatives may be obtained by any of three possible methods: (1) condensation of 4-methyl pyridine with ethyl phthalates in the absence of catalyst; (2) oxidative condensation of N-alkyl-pyridinium bromides with indane-1,3-diones; (3) aminolysis of 2-(4-4H-pyranylidene) indane-1,3-diones.Pharmacomodulation by the introduction of oxygen or sulfur containing functions (ether, thioether, alcohol, ketone, acid, ester, amide) on the nitrogen of the basic molecule is not very fruitful; only the acetic derivative 19 manifests marked antiinflammatory activity unaccompanied by anti-coagulant action.The presence of chloro, nitro or methoxyl groups on 5 after N-substitution by ethyl or piperidinylethyl groups appears to be more favorable.The most active compound 57 decreases prostaglandin production and leukocyte migration without affecting either cyclooxygenase or 5-lipoxygenase.Its interference, direct or indirect, with phospholipasic A2 activity may be envisaged in particular.Keywords - 2-(4-pyridinyl)indane-1,3-diones / heterocyclic β diketoenamines / partition coefficient / anti-inflammatory activity / mechanism of action
- Leblois, Danielle,Piessard, Sylvie,Baut, Guillaume Le,Kumar, Piyush,Brion, Jean-Daniel,et al.
-
p. 229 - 238
(2007/10/02)
-
- Kinetic and equilibrium in the ammonolysis of substituted phthalimides
-
Kinetic studies are reported for the base hydrolysis to phthalamic acid anions (H) and ammonolysis to phthalamides (A) for seven phthalimides (P): 1, unsubstituted; 2, 4-NO2; 3, 4-Cl; 4, 4-tBu; 5, 3-NO2; 6, 3-Me; 7, 3-Me3Si.The hydrolysis kinetics require two mechanisms, one which is first order in neutral imide and first order in hydroxide ion, and a second, which is important only in quite concentrated NaOH, which is first order in neutral phthalimide and second order in hydroxide ion.Ammonolysis kinetics for 1-5 revealed the rate law: Rate = kN ->.A mechanism is proposed with rate-determining breakdown of the anionic form of the tetrahedral intermediate derived by addition of NH3 to the phthalimide.The ammonolysis is reversible.The phthalamide hydrolyzes to the phthalamic acid via cyclization to an intermediate phthalimide, which is detected in concentrated base where its formation from phthalamide is more rapid than its subsequent hydrolysis.Rate constants for the cyclization follow the rate law: Rate = kcyc ->.This reaction is the microscopic reverse of the ammonolysis, and the ratio kN/kcyc provides the equilibrium constant Keq for the reaction P + NH3 = A.Values for 1-5 lie in the range 2 x 102 - 4 x 103.With 3-methylphthalimide, kinetics in aqueous ammonia do not obey a first-order relationship, but they could be analyzed by a scheme whereby the phthalimide is converted reversibly to the phthalamide and simultaneously undergoes an irreversible hydrolysis.The value of Keq in the system is 1.8.With 3-trimethylsilylphthalimide the value of Keq is further reduced to 0.01.The ammonolysis reaction does occur more quickly than hydrolysis but the equilibrium is so unfavorable that even in concentrated ammonia only a small amount of the phthalamide is ever formed.
- McClelland, Robert A.,Seaman, N. Esther,Duff, James M.,Branston, R. E.
-
p. 121 - 128
(2007/10/02)
-
- Remarkably Selective Chlorination of Phthalic Anhydride and Its Monochlorinated Derivatives
-
The vapor-phase chlorination of phthalic anhydride 1 and its monochlorinated derivatives 2 and 3 in the temperature range from 390 to 600 deg C with elemental chlorine has been investigated and found to be highly selective.Thus, chlorination of 1 in the temperature range from 390 to 450 deg C was found to give high yields of monochlorinated products accompanied by only small amounts of dichlorination with a high degree of regioselectivity favoring the formation of 4-chlorophthalic anhydride.Chlorination of a 3-chlorophthalic anhydride 3 by this method has provided thefirst direct synthesis of 3,5-dichlorophthalic anhydride 7 from phthalic anhydride via chlorination.
- Verbicky, John W.,Williams, Louella
-
p. 2465 - 2468
(2007/10/02)
-
- PALLADIUM CATALYZED DECARBONYLATION OF AROMATIC ACYL CHLORIDES
-
A variety of palladium catalysts have been found to effectively promote the decarbonylation of aromatic acyl chlorides at elevated temperatures.
- Verbicky, John W.,Dellacoletta, Brent A.,Williams, Louella
-
p. 371 - 372
(2007/10/02)
-
- Benzocyclobutenes. Part 4. Synthesis of Benzocyclobutene-1,2-diones by Pyrolytic Methods
-
Oxidation of the cyclic hydrazides prepared from phthalic anhydrides in the presence of anthracene gives the corresponding Diels-Alder adducts which, on flash vacuum pyrolysis, give benzocyclobutene-1,2-dione (BBD) and its 4-chloro, 3,6- and 4,5-dichloro, 4,5-dibromo, and 4,5-dimethyl derivatives in 75-98percent yield.Cyclobuta- and cyclobuta-naphthalene-1,2-dione as well as cyclobuta- and cyclobuta-pyridine-1,2-dione have been prepared similarly; the last three of these diones are very unstable.Cyclobutanaphthalene-1,2-dione has also been made by pyrolysis of benzindene-1,2,3-trione.Attempts to make thiophen and furan analogues of BBD from appropriate anthracene adducts failed as did attempts to make tetrachloro- and tetrabromo-derivatives of BBD by the pyrolysis of tetrahalogenophthalimidosulphoximides.
- Gould, Ken J.,Hacker, Nigel P.,McOmie, John F. W.,Perry, David H.
-
p. 1834 - 1840
(2007/10/02)
-
- Aromatic dicarboximides
-
N-(4-aminophenyl)-aromatic dicarboximides, e.g. those of the formula STR1 OR SALTS THEREOF ARE ANTICONVULSANTS.
- -
-
-
- Aromatic dicarboxamides
-
N-(4-aminophenyl)-aromatic dicarboximides, e.g. those of the formula STR1 OR SALTS THEREOF ARE ANTICONVULSANTS.
- -
-
-