cas 118353-05-2, Carbovir | Articles data

Articles about 118353-05-2Total 6 be found

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Synthesis of cyclopentenyl carbanucleosides via palladium(0) catalysed reactions
Methyl 4-acetoxycyclopent-2-enylmethylcarboxylate (2) and the corresponding carbonate 3 have been treated with sodium salts and aluminum amides of pyrimidines, purines and methyl 1H-1,2,4-triazole-3-carboxylate with a catalyst formed from bis(dibenzylideneacetone)palladium(0) and triisopropyl phosphite to give the corresponding carbanucleosides in good to excellent yields. This method was also applied for a synthesis of carbovir (31).
Kapeller,Marschner,Weissenbacher,Griengl
p. 1439 - 1456
(2007/10/03)

π-Allylpalladium formation from allylic amines via N,N-ditosylimides and N-tosylamides: Efficient synthesis of the antiviral agent carbovir
Allylic amines can be easily converted into their N,N-ditosylimides or N-tosylamides which are sufficiently good leaving groups to afford π-allylpalladium complexes and, hence, with nucleophiles, new allylic systems with retention of configuration. The synthetic utility of this process has been demonstrated by an efficient synthesis of the antiviral agent (±)-carbovir (1) from cyclopentadiene in only seven steps and 13% overall yield.
Jung,Rhee
p. 4719 - 4720
(2007/10/02)

New efficient method for the synthesis of the antiviral agent carbovir
An efficient synthesis of (±)-carbovir 1 and simple des(hydroxymethyl) analogues, e.g., 5, is reported which uses a new approach for attaching nucleoside bases to cycloalkene systems.
Jung, Michael E.,Rhee, Hakjune
p. 4449 - 4452
(2007/10/02)

Regiochemistry and Stereochemistry in Pd(0)-Catalyzed Allylic Alkylation of Nucleoside Bases
Allylic alkylation of amino- and hydroxy-azaheterocycles, in particular nucleoside bases, has been effected using Pd(0)-catalysis.A method has been developed for the preparation of carbocyclic nucleoside analogs such as the antiviral agent Carbovir.The synthesis of an appropriately substituted cyclopentenyl acetate for this reaction is described.Carbocyclic nucleosides of thymine at N-1, of adenine at N-9 and guanine at N-9 are described.Regiochemistry and stereochemistry of the products and intermediates have been determined by NMR studies.The (trimethylsilyl)ethyl group has been found to be an excellent protecting group for the 6-OH group in guanine, and it is readily removed by fluoride ions.
Gundersen, Lise-Lotte,Benneche, Tore,Rise, Frode,Gogoll, Adolf,Undheim, Kjell
p. 761 - 771
(2007/10/02)

Pd(0)-catalyzed allylic alkylation in the synthesis of (±)carbovir
Racemic carbovir 1 has been synthesized in 6 steps from the cyclopentanone 8 with a Pd(0)-catalyzed allylation as a key reaction.
Gundersen, Lise-Lotte,Benneche, Tore,Undheim, Kjell
p. 1085 - 1088
(2007/10/02)

Synthesis and anti-HIV activity of carbocyclic 2',3'-didehydro-2',3'-dideoxy 2,6-disubstituted purine nucleosides
(±)-cis-[4-[(2,5-Diamino-6-chloropyrimidinyl)amino]-2-cyclopentenyl]c arbinol (5a) was synthesized from 2-amino-4,6-dichloropyrimidine and cis-4-(hydroxymethyl)cyclopenteylamine (2a) by subsequent preparation of the 5-[(4-chlorophenyl)azo] derivative of t
Vince,Hua
p. 17 - 21
(2007/10/02)

Chemical Properties

Melting Point: 267-269°C
Boiling Point: 605.6 °C at 760 mmHg
Flash Point:320.1 °C
Density: 1.76g/cm³
Solubility:DMSO, Methanol
Storage Temp.:-20?C Freezer
Vapor Pressure: 1.62E-15mmHg at 25°C
Refractive Index: 1.841
PSA: 109.82000
LogP: 0.39250

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Chemical Properties

Melting Point: 267-269°C

Boiling Point: 605.6 °C at 760 mmHg

Flash Point:320.1 °C

Density: 1.76g/cm³

Solubility:DMSO, Methanol

Storage Temp.:-20?C Freezer

Vapor Pressure: 1.62E-15mmHg at 25°C

Refractive Index: 1.841

PSA: 109.82000

LogP: 0.39250

Global suppliers and manufacturers of 118353-05-2total 21 suppliers on LookChem

Article Database

118353-05-2

Articles about 118353-05-2Total 6 be found

More Articles about upstream products of 118353-05-2

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Chemical Properties

Melting Point: 267-269°C

Boiling Point: 605.6 °C at 760 mmHg

Flash Point:320.1 °C

Density: 1.76g/cm3

Solubility:DMSO, Methanol

Storage Temp.:-20?C Freezer

Vapor Pressure: 1.62E-15mmHg at 25°C

Refractive Index: 1.841

PSA: 109.82000

LogP: 0.39250

Global suppliers and manufacturers of 118353-05-2total 21 suppliers on LookChem

Density: 1.76g/cm³