Acyloxymethyl esterification of nodularin-R and microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells
We report the esterification of the carboxyl groups of the cyclic peptide toxins nodularin-R and microcystin-LA to produce stable diacetoxymethyl and dipropionyloxymethyl ester derivatives. The derivatives had no activity but were reactivated upon esteras
Herfindal, Lars,Kasprzykowski, Franciszek,Schwede, Frank,?ankiewicz, Leszek,Fladmark, Kari E.,?ukomska, Joanna,Wahlsten, Matti,Sivonen, Kaarina,Grzonka, Zbigniew,Jastorff, Bernd,D?skeland, Stein Ove
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p. 5759 - 5762
(2010/03/24)
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