Chemical tracer agent for fracturing as well as preparation method and application thereof
The invention relates to a chemical tracer for fracturing and a preparation method and application thereof. The chemical tracer agent is fluoromethyl benzoic acid. The preparation method of the chemical tracer takes p-chlorofluoromethyl benzene as an initial raw material, and comprises a preparation step of a fluoromethyl benzene Grignard reagent, a preparation step of fluoromethyl benzoate and a preparation step of fluoromethyl benzoic acid. The invention further provides application of p-fluoromethyl benzoic acid as a chemical tracer in oil exploitation, trace detection can be realized, and the detection precision is improved.
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Paragraph 0063; 0069-0072; 0075-0076
(2021/05/29)
Transition-metal-free C-H oxidative activation: Persulfate-promoted selective benzylic mono- and difluorination
An operationally simple and selective method for the direct conversion of benzylic C-H to C-F to obtain mono- and difluoromethylated arenes using Selectfluor as a fluorine source is developed. Persulfate can be used to selectively activate benzylic hydrogen atoms toward C-F bond formation without the aid of transition metal catalysts.
Ma, Jing-Jing,Yi, Wen-Bin,Lu, Guo-Ping,Cai, Chun
supporting information
p. 2890 - 2894
(2015/04/27)
LXR MODULATORS
The present invention provides compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXR), compositions comprising any of such novel compounds, methods of using these compounds or compositions as medicaments for prevention or treatment of diseases or disorders related to liver X receptor (LXR), as well as methods of preparing these LXR modulators and using them in the manufacture of medicaments.
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(2014/09/29)
Heterocyclic compounds
The present invention provides a preventive or therapeutic agent for hyperlipidemia, comprising as an active ingredient a heterocyclic compound of the formula [1], or a pharmaceutically acceptable salt thereof: R1-Het-D-E??[1] wherein: R1
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(2008/06/13)
No-carrier-added, 18F-labelling of a cholesterol derivative, used in detection of adrenal malignancies
[18F]Cholesteryl 4-(fluoromethyl)benzoate 6b was prepared from 3-cholesteryl [(4-nitrobenzenesulfonyl)oxymethyl]benzoate in one step using K+-Kryptofix 2.2.2, as counter ion and acetonitrile as the solvent at 40-60°C. The product was
Jalilian, Amir Reza,Bineshmarvasti, Maria,Rafii, Hamid,Afarideh, Hossein,Shafiee, Abbas
p. 747 - 755
(2007/10/03)
Process for introducing fluorine into biologically active materials
Radioactive fluorine can be easily introduced into biologically active molecules containing amino groups. A p-bromomethyl benzoyl group is coupled to the amino group of the biologically active molecule, and bromine is displaced by fluorine. Alternatively,
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(2008/06/13)
A PROSTHETIC GROUP FOR THE RAPID INTRODUCTION OF FLUORINE INTO PEPTIDES AND FUNCTIONALIZED DRUGS
Fluoride ion as the tetrabutylammonium salt displaces bromide in para-substituted benzyl bromides in acetonitrile or dimethylformamide.The p-bromomethyl benzoyl (BMB) group has been coupled to amino groups, including peptide amino groups, via its N-hydrox
Jacobson, Kenneth A.,Furlano, David C.,Kirk, Kenneth L.
p. 339 - 348
(2007/10/02)
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