- Mechanism-guided design of flow systems for multicomponent reactions: Conversion of CO2 and olefins to cyclic carbonates
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A mechanism-guided design of a multi-step flow system enabled an efficient general process for the synthesis of cyclic carbonates from alkenes and CO 2. The flow system proved to be an ideal platform for multicomponent reactions because it was straightforward to introduce reagents at specific stages without their interacting with each other or with reaction intermediates prone to destruction by them. This system exhibited superior reactivity, increased yield, and broader substrate scope relative to conventional batch conditions and suppressed the formation of undesired byproducts, such as, epoxides and 1,2-dibromoalkanes. The Royal Society of Chemistry 2014.
- Wu, Jie,Kozak, Jennifer A.,Simeon, Fritz,Hatton, T. Alan,Jamison, Timothy F.
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p. 1227 - 1231
(2014/03/21)
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- Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14α-demethylase (CYP51)
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Novel cholesterol biosynthesis inhibitors, a group of pyridylethanol(phenylethyl)amine derivatives, were synthesized. Sterol profiling assay in the human hepatoma HepG2 cells revealed that compounds target human lanosterol 14α-demethylase (CYP51). Structu
- Korosec, Tina,Acimovic, Jure,Seliskar, Matej,Kocjan, Darko,Tacer, Klementina Fon,Rozman, Damjana,Urleb, Uros
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p. 209 - 221
(2008/04/12)
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- 2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases
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A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.
- Schnute, Mark E.,Anderson, David J.,Brideau, Roger J.,Ciske, Fred L.,Collier, Sarah A.,Cudahy, Michele M.,Eggen, MariJean,Genin, Michael J.,Hopkins, Todd A.,Judge, Thomas M.,Kim, Euibong J.,Knechtel, Mary L.,Nair, Sajiv K.,Nieman, James A.,Oien, Nancee L.,Scott, Allen,Tanis, Steven P.,Vaillancourt, Valerie A.,Wathen, Michael W.,Wieber, Janet L.
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p. 3349 - 3353
(2008/02/07)
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- Synthesis, conformation, and stereodynamics of a salt of 2-{[2-(3,4-dichlorophenyl)-ethyl]propylamino}-1-pyridin-3-ylethanol
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A novel synthetic route was developed for 2-{[2-(3,4-dichlorophenyl)ethyl] propylamino}-1-pyridin-3-ylethanol (4). A dynamic process due to nitrogen inversion at the central amine nitrogen has been identified by NMR spectroscopy for the dihydrobromide sal
- Korosec, Tina,Grdadolnik, Joze,Urleb, Uros,Kocjan, Darko,Grdadolnik, Simona Golic
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p. 792 - 795
(2007/10/03)
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- 5- substituted tetralones as inhibitors of ras farnesyl trransferase
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The present invention provides novel 5-substituted tetralones of Formulas (I), (II), (III) and (IV) and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme.
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- HETEROARYL-ETHANOLAMINE DERIVATIVES AS ANTIVIRAL AGENTS
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The present invention provides a compound of formula (I), which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.
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