A method of inhibiting parasitic activity is disclosed in which the biosynthesis of the glycosyl phosphatidylinositol (GPI) anchor of said parasite is inhibited by incorporating into said GPI anchor an oxy-substituted fatty acid analog in place of myristate. The inhibitory compounds ar C13 and C14 fatty acids or alkyl esters thereof in which a methylene group normally in carbon position 4 to 13 of said fatty acid is replaced with oxygen.
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(2008/06/13)
Method of inhibiting virus
A method of inhibiting viruses by treatment with oxy- and thio-substituted fatty acid analog substrates of myristoylating enzymes is disclosed. These fatty acid analogs contain an oxygen or sulfur in place of a methylene group in a carbon position from 4 to 13 in the fatty acid chain of a C13 -C14 fatty acid or alkyl ester thereof.
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(2008/06/13)
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