Synthesis of bridged 1,4-diazepane derivatives via Schmidt reactions
A series of bridged 1,4-diazepanes (i.e., diazabicyclo[n.3.2]alkanes, n = 3-5) selectively protected at one of the nitrogen atoms was prepared, for possible application in drug design, via Schmidt rearrangement of the corresponding ketones.
Mityuk, Andrey P.,Denisenko, Aleksandr V.,Dacenko, Oleksandr P.,Grygorenko, Oleksandr O.,Mykhailiuk, Pavel K.,Volochnyuk, Dmitriy M.,Tolmachev, Andrey A.
scheme or table
p. 1790 - 1792
(2010/06/13)
An approach to azabicyclo[ n.3.1]alkanes by double mannich reaction
Chlorotrimethylsilane-promoted double Mannich annulation of ketones using N,N-bis(methoxymethyl)benzylamine has been explored. It has been shown that the structure of the substrate drastically influenced the outcome of the reaction. The method allows azabicyclo[n.3.1]alkane derivatives (n=2-5) to be obtained in good yields. Georg Thieme Verlag Stuttgart New York.
Mityuk, Andrey P.,Denisenko, Aleksandr V.,Dacenko, Oleksandr P.,Grygorenko, Oleksandr O.,Mykhailiuk, Pavel K.,Volochnyuk, Dmitriy M.,Shishkin, Oleg V.,Tolmachev, Andrey A.
experimental part
p. 493 - 497
(2010/04/26)
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