Difluorinated Danishefsky's Diene: A versatile C4 building block for the fluorinated six-membered rings
(equation presented) A Mg(0)/Me3SiCl system was found to be affective for the preparation of difluoro Danishefsky's dienes 2, which involves selective C-F bond cleavage of trifluoromethyl ketones 3. Subsequent hetero Diels-Alder reactions of 2 with aldehydes and imines gave a variety of fluorinated six-membered heterocycles.
FLUORINE-CONTAINING ORGANOZINC REAGENTS. IV. REFORMATSKII-TYPE REACTIONS OF CHLORODIFLUOROACETIC ACID DERIVATIVES
Chlorodifluoroacetic acid has shown to be a promising starting material for Reformatskii-type syntheses of fluorine-containing molecules and thus, it offers an attractive extension to what is known from rather expensive bromodifluoroacetic acid.
Lang, Robert W.,Schaub, Bruno
p. 2943 - 2946
(2007/10/02)
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