- Exploring the importance of piperazine N-atoms for σ2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5- methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-propyl]piperazine (PB28)
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σ2-Agonist 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen- 1-yl)propyl]piperazine (7, PB 28), which proved to revert doxorubicin resistance in breast cancer cells,was taken as a template to prepare new analogs. One of the two basic N-atoms was
- Berardi, Francesco,Abate, Carmen,Ferorelli, Savina,Uricchio, Vincenzo,Colabufo, Nicola A.,Niso, Mauro,Perrone, Roberto
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experimental part
p. 7817 - 7828
(2010/04/30)
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