- Charge balanced fluorescence contrast agent for high signal to background ratio and Method for imaging using the same
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The present invention relates to a charge balanced fluorescence contrast agent, capable of providing a high signal to background ratio when optically observing tissues and cells using a fluorescence imaging device for image guided surgery, wherein the contrast agent emits fluorescence so that the signal to background ratio is detected to be at least 1.1 or greater, wherein the conjugate is represented by chemical formula I.COPYRIGHT KIPO 2019
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Paragraph 0033
(2019/02/26)
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- Near-Infrared Illumination of Native Tissues for Image-Guided Surgery
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Our initial efforts to prepare tissue-specific near-infrared (NIR) fluorescent compounds generated successful correlation between physicochemical properties and global uptake in major organs after systemic circulation and biodistribution. Herein, we focus on the effects on biodistribution based on modulating electronic influencing moieties from donating to withdrawing moieties at both the heterocyclic site and through meso-substitution of pentamethine cyanine fluorophores. These selected modifications harnessed innate biodistribution pathways through the structure-inherent targeting, resulting in effective imaging of the adrenal glands, pituitary gland, lymph nodes, pancreas, and thyroid and salivary glands. These native-tissue contrast agents will arm surgeons with a powerful and versatile arsenal for intraoperative NIR imaging in real time.
- Owens, Eric A.,Hyun, Hoon,Dost, Tyler L.,Lee, Jeong Heon,Park, Gwangli,Pham, Dang Huan,Park, Min Ho,Choi, Hak Soo,Henary, Maged
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p. 5311 - 5323
(2016/07/06)
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- Correlating molecular character of NIR imaging agents with tissue-specific uptake
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Near-infrared (NIR) fluorescent contrast agents are emerging in optical imaging as sensitive, cost-effective, and nonharmful alternatives to current agents that emit harmful ionizing radiation. Developing spectrally distinct NIR fluorophores to visualize sensitive vital tissues to selectively avoid them during surgical resection of diseased tissue is of great significance. Herein, we report the synthetic variation of pentamethine cyanine fluorophores with modifications of physicochemical properties toward prompting tissue-specific uptake into sensitive tissues (i.e., endocrine glands). Tissue-specific targeting and biodistribution studies revealed localization of contrast agents in the adrenal and pituitary glands, pancreas, and lymph nodes with dependence on molecular characteristics. Incorporation of hydrophobic heterocyclic rings, alkyl groups, and halogens allowed a fine-tuning capability to the hydrophobic character and dipole moment for observing perturbation in biological activity in response to minor structural alterations. These NIR contrast agents have potential for clinical translation for intraoperative imaging in the delineation of delicate glands.
- Owens, Eric A.,Hyun, Hoon,Tawney, Joseph G.,Choi, Hak Soo,Henary, Maged
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p. 4348 - 4356
(2015/06/08)
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- NEAR-INFRARED FLUORESCENT CONTRAST BIOIMAGING AGENTS AND METHODS OF USE THEREOF
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The instant invention provides near-infrared fluorescent biological contrast agents and methods of using them.
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Page/Page column 106; 107
(2015/05/19)
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