CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS
Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
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Page/Page column 78
(2014/10/03)
Efficient synthesis of deuterated 1,2,3-triazoles
A wide variety of 1-monosubstituted 1,2,3-triazoles were synthesized efficiently via a copper-catalyzed click-reaction between azides and acetylene gas, generated in situ from CaC2 with the addition of H2O or D2O.
Gonda, Zsombor,Lrincz, Krisztián,Novák, Zoltán
supporting information; experimental part
p. 6275 - 6277
(2011/01/04)
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