- 2-OXAZOLIDINONES AND THEIR USE AS INHIBITORS OF ANIMAL CELL MOTILITY AND GROWTH
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Cell motility and growth inhibitors, including compounds of the general structural formula (I), and use of the cell motility and cell growth inhibitors, and pharmaceutically acceptable salts, pro-drugs, and solvates thereof, as therapeutic agents, are disclosed.
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- Electrochemically induced N-acryloylation of chiral oxazolidin-2-ones
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A new method for N-acryloylation of Evans' chiral auxiliaries (oxazolidin-2-ones) with α,α′-dichloro ketones in the presence of the electrogenerated base 2-pyrrolidone anion is described. N-Enoyloxazolidin-2-ones are obtained, under mild reaction conditions, in good to high yields.
- Feroci, Marta,Inesi, Achille,Rossi, Leucio,Sotgiu, Giovanni
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p. 2765 - 2769
(2007/10/03)
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- The Asymmetric Synthesis of α-Amino and α-Hydrazino Acid Derivatives via The Stereoselective Amination of Chiral Enolates with Azodicarboxylate Esters.
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The utility of azodicarboxylate esters as (+)NH2 and (+)NH-NH2 synthons in highly diastereoselective reactions with chiral carboximide-derived enolates has been demonstrated.The lithium enolates derived from 4-substituted N-acyl 2-oxazolidinones were found to react with di-tert-butyl azodicarboxylate (DBAD) to afford the derived 2-hydrazido carboxylic acid derivetives in yields in excess of 90 percent.The diastereoselectivities of these reactions ranged from 97percent to greater than 99percent.The subsequent transformation of these adducts to both α-hydrazino and α-amino acids in enantiomeric purities in excess of 99percent is described.
- Evans, David A.,Britton, Thomas C.,Dorow, Roberta L.,Dellaria, Joseph F.
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p. 5525 - 5540
(2007/10/02)
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