Convenient synthesis of N-Terminal Tfm-Dipeptides from unprotected enantiopure α-Tfm-Proline and α-Tfm-alanine
A convenient procedure for the synthesis of highly lipophilic dipeptide building blocks from enantiopure α-trifluoromethyl α-amino acids is reported. Coupling reactions at the C termini of the trifluoromethyl a-amino acids were successfully performed with