(+)-4-Phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist
A new synthesis of (R,S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)- and (-)-PPG are described. Pharmacological characterization at the group III metabotropic glutamate receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the active enantiomer. (C) 2000 Elsevier Science Ltd. All rights reserved.
Gasparini, Fabrizio,Inderbitzin, Werner,Francotte, Eric,Lecis, Gabrielle,Richert, Paul,Dragic, Zorica,Kuhn, Rainer,Flor, Peter J.
p. 1241 - 1244
(2007/10/03)
(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo
Group III metabotropic glutamate receptors (mGluRs) are thought to modulate neurotoxicity of excitatory amino acids, via mechanisms of presynaptic inhibition, such as regulation of neurotransmitter release. Here, we describe (R,S)-4-phosphonophenylglycine
Gasparini,Bruno,Battaglia,Lukic,Leonhardt,Inderbitzin,Laurie,Sommer,Varney,Hess,Johnson,Kuhn,Urwyler,Sauer,Portet,Schmutz,Nicoletti,Flor, Peter J.
p. 1678 - 1687
(2007/10/03)
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