- Synthesis and in vitro cytotoxic evaluation of new triazole derivatives based on artemisinin via click chemistry
-
The paper presents the synthesis of new artemisinin triazole derivatives via click chemistry and their in vitro cytotoxic evaluation against four cancer cell lines including MCF-7, LU-1, HL-60 and P388. The bioassay result showed that most of the target compounds were active against four cell lines, in which compounds 11g displayed the most potent inhibitory activity against HL-60 cell line with IC50 value of 2.5 μM.
- Binh, Le Huy,Van, Nguyen Thi Thuy,Kien, Vu Tuan,My, Nguyen Thi Thuy,Van Chinh, Luu,Nga, Nguyen Thi,Tien, Hoang Xuan,Thao, Do Thi,Vu, Tran Khac
-
p. 738 - 750
(2016/03/08)
-
- Chemoselective reduction of azides catalyzed by molybdenum xanthate by using phenylsilane as the hydride source
-
A chemoselective, neutral, and efficient strategy for the reduction of azides to corresponding amines catalyzed by dioxobis(N,N,-diethyldithiocarbamato) molybdenum complex (1, MoO2[S2CNEt2]2) in the presence of phenylsilane is discovered. This chemoselective reduction strategy tolerates a variety of reducible functional groups.
- Maddani, Mahagundappa R.,Moorthy, Saravana K.,Prabhu, Kandikere R.
-
supporting information; experimental part
p. 329 - 333
(2010/03/01)
-