- A Facile Synthesis of Dialkoxycarbonylketene-, Dicyanoketene-, and Alkoxycarbonyl(cyano)ketene Ethylene Acetals
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Dicyanoketene-, dialkoxycarbonylketene-, and alkoxycarbonyl(cyano)ketene ethylene acetals can be conveniently prepared by reaction of malononitrile, dialkyl malonates and alkyl cyanoacetates with 2-chloroethyl chloroformate.
- Neidlein, Richard,Kikelj, Daniel
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- SOLID FORMS OF ISOQUINOLINONE DERIVATIVES, PROCESS OF MAKING, COMPOSITIONS COMPRISING, AND METHODS OF USING THE SAME
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Solid forms of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphic forms, cocrystals, and amorphous forms thereof, and pharmaceutical compositions thereof.
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Paragraph 001162; 001163; 001164
(2017/04/11)
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