Chemokine receptor binding heterocyclic compounds with enhanced efficacy
The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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(2008/06/13)
New Methodology for the Synthesis of Protected, Primary Pentadienylamines
The utility of forming N-tert-butoxycarbonyl- (Boc) and N-phthalimido-protected primary 2(E),4(E)-pentadienylamines from aldehydes and ketones is described.When diethyl -2-buten-1-yl>phosphonate (33E) is treated with s
Connel, Richard D.,Helquist, Paul,Akermark, Bjoern
p. 3359 - 3370
(2007/10/02)
5'-{[(Z)-4-amino-2-butenyl]methylamino}-5'-deoxy-adenosine: A potent enzyme-activated irreversible inhibitor of S-adenosyl-L-methionine decarboxylase from Escherichia coli
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Casara,Marchal,Wagner,Danzin
p. 9111 - 9113
(2007/10/02)
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