- HPK1 INHIBITORS, PREPARATION METHOD AND APPLICATION THEREOF
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Disclosed are HPK-1 inhibitors having a structure represented by Formula (X), pharmaceutical compositions comprising the HPK-1 inhibitors, methods of using the HPK-1 inhibitors, such as treating cancers, methods of preparing the HPK-1 inhibitors, and the synthetic intermediates.
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Page/Page column 178
(2019/11/12)
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- Substrate-promoted copper-catalyzed N-arylation of amino alcohols with aryl iodides in water
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An efficient method has been developed for the N-arylation of a variety of water-soluble amino alcohols (1.2 mmol) with aryl iodides (1.0 mmol) in water under CuI-catalyzed conditions. The reaction was conducted via substrate-promoted action and did not require an additional ligand or phase-transfer catalyst, and afforded the desired N-aryl amines in acceptable to excellent yields (64%-93%) under mild reaction conditions with a small excess of the amino alcohol.
- Jin, Ming,Zhao, Dan,He, Guozhen,Tong, Yao,Han, Shiqing
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p. 1651 - 1655
(2013/10/21)
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- Solvent-free copper-catalyzed N-arylation of amino alcohols and diamines with aryl halides
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A simple and mild method for the coupling of aryl halides with amino alcohols and diamines is described. The reactions can be performed under ligand-free and solvent-free conditions, and generate the products in good yield.
- Yin, Huiqing,Jin, Ming,Chen, Wei,Chen, Chen,Zheng, Likang,Wei, Ping,Han, Shiqing
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supporting information; experimental part
p. 1265 - 1270
(2012/03/27)
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- MORPHOLINYL CONTAINING BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION
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The present invention concerns morpholinyl containing benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula (I), a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereoc
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Page/Page column 52
(2010/02/12)
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