Catechol-bearing imidazolium and benzimidazolium chlorides as promising antimicrobial agents
Catechol-containing imidazolium (four) and benzimidazolium chlorides (eight) were synthesized to evaluate their antimicrobial properties. All the compounds were fully characterized using 1H and 13C nuclear magnetic resonance, liquid
Karata?, Mert O.,Günal, Selami,Mansur, Ahmet,Al?c?, Bülent,?zdemir, ?smail
Oral Hypoglycemic Agents. Discovery and Structure-Activity Relationships of Phenacylimidazolium Halides
Blood glucose levels in viable, yellow, obese, diabetic mice are reduced following oral administration of phenacylimidazolium halides.Compounds 2 and 3 produced reductions of ca. 40percent 2 h after doses of 100 mg/kg po.Since these mice do not respond to sulfonylureas, the glucose-lowering activity of phenacylimidazolium salts in this model suggests a mechanism other than that of stimulating insulin secretion.Only phenacylimidazolium halides with electron-donating groups were active; other azolium salts or variations in the phenacyl portion (alterations in the keto function; chain lengthening or extensive branching) produced inactive compounds.
Dominianni, Samuel J.,Yen, Terence T.
p. 2301 - 2306
(2007/10/02)
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