Concise Stereoselective Synthesis of (2S,4R)-4-Hydroxyproline from (S)-O-Benzylglycidol by a Novel Cyclization
An efficient stereoselective route to (2S,4R)-4-hydroxyproline from (S)-O-benzylglycidol has been established via a novel iodine-mediated cyclization of the N-benzoyl-γ,δ-unsaturated amide.