- Diversity-Oriented Synthesis of Steviol Glycosides
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With cheap and easily available mixtures of steviol glycosides as starting materials, a practical method for steviol acquisition has been developed, on the basis of which a facile, diversity-oriented, and economic protocol for the synthesis of structurally defined steviol glycosides was established. The novel approach is featured by the highly efficient glycosylation of sterically hindered and acid-sensitive steviol via orchestrated application of Yu glycosylation, Schmidt glycosylation, and PTC glycosylation. Hence, these high-intensity sweeteners and potential lead compounds for drug development are now readily accessible.
- Qiao, Zhi,Liu, Hui,Sui, Jing-Jing,Liao, Jin-Xi,Tu, Yuan-Hong,Schmidt, Richard R.,Sun, Jian-Song
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p. 11480 - 11492
(2018/09/25)
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- HIGH-PURITY STEVIOL GLYCOSIDES
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Methods of preparing highly purified steviol glycosides, particularly rebaudiosides A, D and M are described. The methods include utilizing recombinant microorganisms for converting various staring compositions to target steviol glycosides. In addition, novel steviol glycosides reb D2, reb M2, and reb I are disclosed, as are methods of preparing the same. The highly purified rebaudiosides are useful as non-caloric sweetener in edible and chewable compositions such as any beverages, confectioneries, bakery products, cookies, and chewing gums.
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Page/Page column 80
(2016/04/09)
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- Novel Process for the Preparation of Rebaudioside D and Other Related Naturally Occurring Sweetners
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A novel process for preparation of Rebaudioside D (RD), and other related naturally occurring sweeteners is provided. RD is a natural sweetening agent which can decrease the bitter aftertaste of steviol glycosides. The said process is suitable for commercial manufacturing by using readily available natural products and nontoxic reagents.
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Paragraph 0175
(2014/10/16)
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