A direct approach to the synthesis of famciclovir and penciclovir
Reaction of 2-amino-6-chloropurine with triethyl 3-bromopropane-1,1,1- tricarboxylate followed by decarbethoxylation/transsesterification of the unpurified product was the key sequence in sythesising both the anti- herpesvirus agent penciclovir and its form famciclovir in three isolated steps.
Choudary, Bernadette M.,Geen, Graham R.,Kincey, Peter M.,Parratt, Martin J.,Dales, J. Robert M.,Johnson, Graham P.,O'Donnell, Steven,Tudor, David W.,Woods, Neil
p. 981 - 994
(2007/10/03)
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