The invention relates to compounds of formula (I)wherein M represents a 5-membered heterocyclic aromatic ring and A is defined in the description. Further, the use of said compounds as antibacterial agents, especially against Gram-negative microorganismsn
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Page/Page column 60
(2019/03/12)
A systematic study of Suzuki-Miyaura cross-coupling reactions on thiazoleboronic esters in the 4- and 5-position
A systematic study of the Suzuki-Miyaura cross-coupling reaction of thiazoleboronic esters under microwave conditions is presented. Boronic acid esters were prepared in the 4- and 5-position of the thiazole ring and subsequently cross-coupled with a number of different (hetero)aryl halides. Yields of the coupling process depended on the reactivity of the boronic acid at the particular position in the thiazole system, as hydrolysis and subsequent deboronation was found to be a major side reaction. Georg Thieme Verlag Stuttgart.
Schnuerch, Michael,Haemmerle, Johanna,Mihovilovic, Marko D.,Stanetty, Peter
experimental part
p. 837 - 843
(2010/09/18)
A guideline for the arylation of positions 4 and 5 of thiazole via Pd-catalyzed cross-coupling reactions
The arylation of thiazoles in 4- and 5-position was investigated in detail. Suzuki-Miyaura and Stille cross-coupling reactions were tested using thiazoles either as halide or organometal species. The obtained results were critically compared to develop he
H?mmerle, Johanna,Schnürch, Michael,Iqbal, Naseer,Mihovilovic, Marko D.,Stanetty, Peter
scheme or table
p. 8051 - 8059
(2010/10/21)
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