An inverse electron demand hetero-Diels-Alder reaction between 2-acylamino-methylene-3-oxobutanoic acid derivatives (5) and ketene acetals (6) yields crystalline dihydropyrans, which are versatile intermediates in the synthesis of carbapenems.
Bayles, Richard,Flynn, Anthony P.,Galt, Ronald H.B.,Kirby, Susan,Turner, Ralph W.
p. 6341 - 6344
(2007/10/02)
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