Concise synthesis of polymethoxyflavone sudachitin and its derivatives, and biological evaluations
We accomplished a divergent synthesis of sudachitin (2), a polymethoxyflavone isolated from citrus fruits, and six derivatives from acetophenone 9, which was an intermediate in our previous synthesis of nobiletin (1). Compound 2 enhanced glucose-induced i
A new clomiphene metabolite, extremely useful for doping analysis, was synthesized in 19% overall yield. The approach involved a Grignard reaction via a N-acylbenzotriazole intermediate to afford a key aromatic ketone and a HWE reaction. Both stereo-isomers were separated and identified. Georg Thieme Verlag Stuttgart ? New York.
Vitoriano, Bruno C.,Carvalho, Luísa C. R.,Estev?o, Mónica S.,Sekera, Michael H.,Marques, M. Manuel B.
supporting information; experimental part
p. 753 - 756
(2010/06/13)
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