- The use of Curtius rearrangement in the synthesis of 4- aminothiazolidines
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The amine group of the L-cysteine was protected as (4R)-1,3- thiazolidines-4-carboxylic acids 2a-b and was used for the synthesis of functionalized 1,3-diamines by the way of Curtius reaction. An optimization of this methodology was made using the acylation in situ of the amine group of the thiazolidines and the activation of the carboxylic acid, after Curtius rearrangement yielded the ureas 7a,b and 8a and amine derivatives 6a,b. The Curtius reaction occurred without racemization, preserving the chemical and pharmacological importance of these products.
- Braibante, Mara E.F.,Braibante, Hugo S.,Costenaro, Edson R.
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p. 943 - 946
(2007/10/03)
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