Radical-mediated synthesis of trifluoroethyl amines and trifluoromethyl ketones from alkyl iodides
Radical reaction of alkyl iodides with trifluoromethyl phenylsulfonyl oxime ether 10 and hexamethylditin at 300 nm in benzene afforded the corresponding trifluoromethyl oxime ethers 11 in high yields, which were reduced into the 2,2,2-trifluoroethyl amines with lithium aluminium hydride. The trifluoroethyl amines could be converted into the corresponding trifluoromethyl ketones by treatment with NBS and DBU.
Kim, Sunggak,Kavali, Rajesh
p. 7189 - 7191
(2007/10/03)
A New Synthesis of 1-(Trifluoromethyl)enamines and 1-(Trifluoromethyl)alkylamines
Several 1-(trifluoromethyl)enamines were prepared by heating trifluoroacetamides with alkylidenetriphenylphosphoranes in THF or benzene.The product enamines can be reduced (H2, Pd/C) to 1-(trifluoromethyl)alkylamines.
Begue, Jean-Pierre,Mesureur, Dany
p. 309 - 312
(2007/10/02)
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