- Rapid and controllable covalent functionalization of single-walled carbon nanotubes at room temperature
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We report a rapid and efficient procedure to functionalize SWNT where free radicals generated at room temperature by a redox reaction between reduced SWNT and diacyl peroxide derivatives were covalently attached to the SWNT wall. The Royal Society of Chemistry.
- Martinez-Rubi, Yadienka,Guan, Jingwen,Lin, Shuqiong,Scriver, Christine,Sturgeon, Ralph E.,Simard, Benoit
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- Sidewall Carboxylic Acid Functionalization of Single-Walled Carbon Nanotubes
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The reactions of single-walled carbon nanotubes (SWNTs) with succinic or glutaric acid acyl peroxides in o-dichlorobenzene at 80-90 °C resulted in the addition of 2-carboxyethyl or 3-carboxypropyl groups, respectively, to the sidewalls of the SWNT. These acid-functionalized SWNTs were converted to acid chlorides by derivatization with SOCl2 and then to amides with terminal diamines such as ethylenediamine, 4,4′ -methylenebis(cyclohexylamine), and diethyltoluenediamine. The acid-functionalized SWNTs and the amide derivatives were characterized by a set of materials characterization methods including attenuated total reflectance (ATR) FTIR, Raman and solid state 13C NMR spectroscopy, transmission electron microscopy (TEM), and thermal gravimetry-mass spectrometry (TG-MS). The degree of SWNT sidewall functionalization with the acid-terminated groups was estimated as 1 in 24 carbons on the basis of TG-MS data. In comparison with the pristine SWNTs, the acid-functionalized SWNTs show an improved solubility in polar solvents, for example, alcohols and water, which enables their processing for incorporation into polymer composite structures as well as for a variety of biomedical applications.
- Peng, Haiqing,Alemany, Lawrence B.,Margrave, John L.,Khabashesku, Valery N.
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- METHOD OF DRUG DELIVERY BY CARBON NANOTUBE-CHITOSAN NANOCOMPLEXES
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Functionalized Single Wall Carbon Nanotube (SWCNT) complexed with nanochitosan for use in the delivery of bioaffecting substances and diagnostic applications. fSWCNT complexed with the chitosan NG042 were used for delivery of DNA-encoding EGFP reporter protein and peptide. The results demonstrate that shown CNT-chitosan hybrid nanoparticles exhibit significantly higher transfection efficiency in vivo than chitosan alone. Furthermore, the functionalized nanotubes were tested for peptide transfer into HEK293 cells. The results showed that the hybrid nanoparticles efficiently transferred peptides. Together, these results show that hybrid SWCNT-chitosan particles increase DNA and peptide transfer into cells.
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(2008/12/05)
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