- FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
-
The present invention provides a fluorine-containing triazolopyridine represented by formula (I) and a racemate, R-stereoisomer, S-stereoisomer, pharmaceutically acceptable salt, or mixture thereof. The triazolopyridine can be used as a positive allosteri
- -
-
Page/Page column 0077
(2019/04/16)
-
- POLYCYCLIC TLR7/8 ANTAGONISTS AND USE THEREOF IN THE TREATMENT OF IMMUNE DISORDERS
-
The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroary; and X is C(R4)2, O, NR4, S, S(R4), or S(R4)2.
- -
-
Paragraph 00782
(2017/07/06)
-
- Rate constant for the ring opening of the 2,2-difluorocyclopropylcarbinyl radical
-
(figure presented) The rate constant for the unimolecular ring opening of the 2,2-difluorocyclopropylcarbinyl radical was determined via its competitive bimolecular trapping by TEMPO. The value of this rate constant (3.4 × 1011 s-1 a
- Tian, Feng,Dolbier Jr., William R.
-
p. 835 - 837
(2007/10/03)
-
- 2,2-difluorocyclopropylethane derivatives, processes for their preparation and their use as pesticides
-
There are provided new 2,2-difluorocyclopropylethane derivatives of general formula I STR1 in which A, B and R1-5 have the meanings given in the description and processes for their preparation. The compounds of the invention can be used as pest
- -
-
-