Synthesis and photochromic properties of 2-(3-nitro-2-pyridylmethyl)benzazoles
2-(3-Nitro-2-pyridylmethyl)benzazoles were synthesized, and their photochromic properties were studied by flash photolysis. Introduction of a nitropyridyl instead of the nitrophenyl moiety into the 2-methyl group insignificantly increases the basicity of the methylene group. Nitropyridyl-substituted benzazoles give rise to three detectable photoinduced forms: the corresponding union at pH > 10, azamerocyanine at pH ≈ 4, and monomethinecyanine at pH ≈ 1. Irradiation of solutions of weakly basic henzoxazole and benzothiazole derivatives at pH ≈ 4 results in formation of neutral chelate structures in which the hydrogen atom is linked simultaneously to two nitrogen atoms: one in the pyridine ring, and the second, in the azole ring.
1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT6 receptor ligands
1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines were prepared. Binding assays indicated they are 5-HT6 receptor ligands, among which 6f and 6g showed high affinity for 5-HT6 receptors with Ki = 3.9 and 1.7 nM, respectively.
Bernotas, Ronald C.,Antane, Schuyler A.,Lenicek, Steven E.,Haydar, Simon N.,Robichaud, Albert J.,Harrison, Boyd L.,Zhang, Guo Ming,Smith, Deborah,Coupet, Joseph,Schechter, Lee E.
scheme or table
p. 6935 - 6938
(2010/06/16)
Synthesis of Some Nitropyridylacetonitriles
A new synthesis of nitropyridylacetonitriles 4 has been developed, using tert-butyl cyanoacetate and the corresponding chloropyridines 2.The tert-butyl esters are removed by acid-catalyzed dealkoxycarbonylation.
Katz, R. B.,Voyle, M.
p. 314 - 316
(2007/10/02)
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