- Hypocrellin derivative containing long-chain quaternary ammonium salt, and preparation method and application thereof
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The invention discloses a hypocrellin derivative containing a long-chain quaternary ammonium salt, and a preparation method and an application thereof. The structural general formula of the derivative is represented by formula (1) or formula (2) shown in the description. In the formula (1) and the formula (2), X is N, O or S; m is not lower than 2 and not greater than 20, n is not lower than 0 and not greater than 10, p is not lower than 1 and not greater than 2, and m, n and p are positive integers; R1, R2 and R3 are C1-C20 alkyl groups respectively; HA is hypocrellin A; and HB is hypocrellin B. Hypocrellin is modified with long-chain quaternary ammonium salt for the first time, so the water solubility and the biocompatibility of the hypocrellin are enhanced; and the derivative has good oil and water amphipathicity, can effectively combine negatively charged species in organisms, and especially has very good nucleophilicity to tumor cells. The hypocrellin derivative containing a long-chain quaternary ammonium salt can be directly dissolved in normal saline to prepare a preparation medicine, so the medicinal effect of the derivative is improved, and development of hypocrellin medicines for treating cancers and preventing cancer viruses is possible.
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Paragraph 0064; 0065; 0066
(2016/10/27)
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- Method for preparing hypocrellin
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Improved methods of preparing hypocrellin B from 4,9-dihydroxy-3,10-perylenequinones are described.
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Page/Page column 4
(2010/11/03)
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