cas 124-90-3, OXYCODONE HYDROCHLORIDE | Articles data

Articles about 124-90-3Total 15 be found

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Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone
Improved processes for making opioid products having low impurity levels including making 14-hydroxycodeinone and 14-hydroxymorphinone from thebaine and oripavine, respectively.
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(2016/03/14)

CONVERSION OF OXYCODONE BASE TO OXYCODONE HYDROCHLORIDE
Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
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(2015/06/24)

SYNTHESIS OF OXYCODONE HYDROCHLORIDE
Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
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(2015/06/24)

PROCESS FOR IMPROVED OPIOID SYNTHESIS
Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxycodone base and/or an oxycodone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.
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(2014/02/15)

A METHOD FOR PREPARING OXYCODONE
The present invention provides a process for preparing an oxycodone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxycodeinone and an acid to form a solution of the oxycodone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than ambient temperature in the presence of a hydrogenation catalyst and hydrogen gas, wherein the solution of oxycodone acid adduct comprises 6α-oxycodol in an amount ≤ about 0.800 area % as determined by HPLC.
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Page/Page column 31; 32

(2014/02/16)

PROCESS
The present invention provides a process for preparing an oxycodone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxycodeinone and an acid to form a solution of the oxycodone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than ambient temperature in the presence of a hydrogenation catalyst and hydrogen gas, wherein the solution of oxycodone acid adduct comprises 6α-oxycodol in an amount ≦about 0.800 area % as determined by HPLC.
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Paragraph 0181

(2014/03/21)

PROCESS FOR THE SYNTHESIS AND PURIFICATION OF OXYCODONE
A method of preparing oxycodone includes forming 14-hydroxycodeine by reduction of 14-hydroxycodeinone and rearrangement of the 14-hydroxycodeine to form the oxycodone. During the reduction step, the ketone group of an undesirable contaminant precursor, 8, 14-dihydroxy-7,8-dihydrocodeinone, is reduced to a hydroxyl group thus forming a triol. This triol is substantially inert with respect to reforming 14- hydroxycodeinone and can be readily separated from oxycodone.
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(2012/01/15)

Preparation of low impurity opiates in a continuous flow reactor
The present invention relates to a novel process for preparing opiates or salts thereof. More particularly, the present invention relates to oxidizing the starting material in a continuous flow reactor, followed by either an isolation of the intermediate, or a direct reduction reaction.
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Page/Page column 6

(2011/11/01)

Process For Preparing Oxycodone Having Reduced Levels Of 14-Hydroxycodeinone
The present invention is directed to processes for preparing oxycodone base and oxycodone hydrochloride compositions having less than 10 ppm of 14-hydroxycodeinone.
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Page/Page column 6

(2008/12/06)

Process for Reducing Impurities in Oxycodone Base
The present invention is directed to a process for using n-butanol to prepare an oxycodone base compositions having reduced levels of impurities such as 14-hydroxycodeinone and DHDHC.
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Page/Page column 6

(2008/12/05)

PROCESSES FOR PREPARING MORPHINAN-6-ONE PRODUCTS WITH LOW LEVELS OF ALPHA, BETA-UNSATURATED KETONE COMPOUNDS
The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of alpha, beta unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound.
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Page/Page column 27-29

(2008/06/13)

Preparation of oxycodone
A process for preparing oxycodone or an oxycodone salt, wherein the oxycodone or oxycodone salt has low levels of impurities (especially 14-hydroxycodeinone) is disclosed. The process comprises the steps of: a) preparing a mixture comprising oxycodone and a solvent and adjusting the pH of the mixture to less than 6; and subsequently b) exposing the mixture to hydrogenation reagents for a period of at least 1 hour.
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Page/Page column 3-4

(2008/06/13)

A METHOD OF PREPARATION OF OXYCODONE
A method of preparation of Oxycodone of formula (I) by reacting thebaine of formula (II), or its analogue of formula (III), wherein R represents a C2 to C5 alkyl, an alkylaryl, preferably benzyl, methoxybenzyl, or alkyl, with hydrogen peroxide or peroxoacids in the presence of oxalic acid in admixture with acetic or formic acid. From the resulting crystalline precipitate of 14-hydroxycodeinone oxalate, by addition of a base, 14-hydroxycodeinone of formula (IV) is released, which is hydrogenated with hydrogen in the presence of a catalyst to yield Oxycodone (I): Oxycodone is transformed to hydrochloride, which is used as the active ingredient in analgesic formulations.
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Page/Page column 7-8

(2008/06/13)

Process for manufacturing opioid analgesics
Oxycodone is manufactured in high yields and with a high purity using a composition including a thebaine component into 14-hydroxycodeinone and then reduction of 14-hydroxycodeinone to oxycodone.
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(2008/06/13)

OXYCODONE-HYDROCHLORIDE POLYMORHS
Oxycodone?HCl polymorph forms are disclosed which are useful as analgesic agents either in combination with or as replacements for oxycodone.
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Page 5

(2008/06/13)

Chemical Properties

Appearance/Colour :White solid
Melting Point: 261-263 °C
Boiling Point: 501.6 °C at 760 mmHg
Flash Point:257.1 °C
Density: 1.39 g/cm³
Solubility:Freely soluble in water, sparingly soluble in anhydrous ethanol, practically insoluble in toluene.
Storage Temp.:2-8°C
Vapor Pressure: 7.02E-11mmHg at 25°C
PSA: 59.00000
LogP: 1.78810

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124-90-3

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Chemical Properties

Appearance/Colour :White solid

Melting Point: 261-263 °C

Boiling Point: 501.6 °C at 760 mmHg

Flash Point:257.1 °C

Density: 1.39 g/cm³

Solubility:Freely soluble in water, sparingly soluble in anhydrous ethanol, practically insoluble in toluene.

Storage Temp.:2-8°C

Vapor Pressure: 7.02E-11mmHg at 25°C

PSA: 59.00000

LogP: 1.78810

Article Database

124-90-3

Articles about 124-90-3Total 15 be found

More Articles about upstream products of 124-90-3

More Articles about downstream products of 124-90-3

Chemical Properties

Appearance/Colour :White solid

Melting Point: 261-263 °C

Boiling Point: 501.6 °C at 760 mmHg

Flash Point:257.1 °C

Density: 1.39 g/cm3

Solubility:Freely soluble in water, sparingly soluble in anhydrous ethanol, practically insoluble in toluene.

Storage Temp.:2-8°C

Vapor Pressure: 7.02E-11mmHg at 25°C

PSA: 59.00000

LogP: 1.78810

Density: 1.39 g/cm³