Evaluation of ethyl: N -(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus
A small molecule library consisting of 45 compounds was synthesized based on the bacterial metabolite ethyl N-(2-phenethyl) carbamate. Screening of the compounds revealed a potent analogue capabale of inhibiting several strains of Methicillin Resistant S. aureus biofilms with low to moderate micromolar IC50 values.
Stephens, Matthew D.,Yodsanit, Nisakorn,Melander, Christian
p. 6853 - 6856
(2016/07/21)
Synthesis of carbamates from amines and dialkyl carbonates: Influence of leaving and entering groups
A number of carbamates were synthesised through a halogen-free process by reacting amines with symmetrical and unsymmetrical carbonates. The results obtained showed a specific trend of preferred leaving groups (in the dialkyl carbonates) depending on whether a catalyst or a base was used. On the other hand, investigations conducted on the preferred entering groups (amines) for the synthesis of carbamates showed the same trend regardless of whether a catalyst or a base was used. Finally, in accordance with the results obtained, it was possible to synthesise sterically hindered carbamates in high yield by transesterification of methyl carbamate with a sterically hindered alcohol. Georg Thieme Verlag Stuttgart New York.
Tundo, Pietro,McElroy, C. Robert,Aricò, Fabio
experimental part
p. 1567 - 1571
(2010/09/05)
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