- Saddling up copper-new twists on a metallo-wheel
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A unique octanuclear copper(ii) cluster with a saddle-shaped structural topology has been prepared from a large, flexible polydentate ligand comprising a 4,4′-bipyridine linker bearing four pendant pyrazolate heterocycles.
- Zarrabi, Niloofar,Hayward, John J.,Clegg, William,Pilkington, Melanie
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- The activated core approach to combinatorial chemistry: A selection of new core molecules
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Four new activated core molecules suitable for use in solution-phase combinatorial organic chemistry have been prepared. These molecules represent an attempt to further explore shape-space and increase the structural diversity of prepared libraries, as well as to incorporate recognition elements in the cores to increase the chances for interaction with biological targets. Demonstrations of deconvolution strategies used to simplify complex libraries and build individual molecular species based on the cores are also provided.
- Pryor, Kent E.,Shipps Jr., Gerald W.,Skyler, David A.,Rebek Jr., Julius
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p. 4107 - 4124
(2007/10/03)
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- A Convenient Synthesis of 2,2',6,6'-Tetramethyl-4,4'-bipyridine and Its Oxidation to 2,2',6,6'-Tetracarboxy-4,4'-bipyridine
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By reaction of 2,6-dimethylpyridine (1b) with sodium the tetrahydro-4,4'-bipyridine bis-sodium salt 2b is formed.Of different dehydrogenation reagents tested, only sulfur dioxide affords the title compound 3b, in 49percent overall yield.By oxidation of 3b with chromium trioxide, 2,2',6,6'-tetracarboxy-4,4'-bipyridine (3c, 70percent) is produced, a valuable precursor for several 2,2',6,6'-tetrasubstituted 4,4'-bipyridines, e.g., the corresponding acid chloride 3d and the carboxylic esters 3e and 3f.
- Huenig, Siegfried,Wehner, Ingeborg
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p. 552 - 554
(2007/10/02)
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