- Design and synthesis of pyrrolo[2,1-c][1,4]benzodiazepine (PBD)- polyaminoalkyl conjugates by the use of SNAr reaction of 2-nitro-5-fluorobenzoate precursor as key reaction
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The design and synthesis of a series of pyrrolo[2,1-c][1,4]benzodiazepine (PBD)- polyaminoalkyl conjugates as DNA minor groove binders are described. To introduce polyaminoalkyl groups to the pyrrolo[2,1-c][1,4]benzodiazepine pharmacophore, SNA
- Iida, Hirokazu,Hayashi, Naoto,Lown, J. William,Matsumoto, Kiyoshi
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p. 693 - 711
(2007/10/03)
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- Multi-layer macromonocyclic polyamines. I. Molecular design and synthesis of component monocyclic precursors
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We designed 'multi-layer macromonocyclic polyamines' which might be appropriate polymorphismic molecular scaffolds as host-molecules in ionic or molecular interaction with small or large guest ions or molecules. In polymorphismic molecules, several macromonocyclic polyamines with the same and/or different ring sizes and nitrogen contents are connected to each other by alkylene spacers with various length of the chain. Actual target molecules are characterized by possessing methylene chain arrays of natural polyamines, and we have synthesized from simple starting materials fourteen component macromonocycles with various sizes, 12- to 34-membered rings containing three to eight nitrogen atoms, as essential building blocks required for construction of multi-layer molecules. Our method of synthesis was shown to be very efficient. In a final step, the N-protecting benzyl group was successfully removed by hydrogenation on 10%-Pd/C under 4 kg cm-2 H2 to give the cyclic amine precursors, which could be internal and terminal components in the architecture of the multi-layer molecules. The structures of synthesized compounds were characterized and confirmed by EA, 1H NMR, SIMS, and FAB(+) mass spectrometry.
- Iwata, Masaaki
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p. 693 - 704
(2007/10/03)
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- Synthesis of polyaminoalkyl substituted conjugates of pyrrolo[2,1- c][1,4]benzodiazepine involving S(N)Ar reaction of 2-nitro-5-fluorobenzoate precursors
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A synthetic procedure is described for conjugating polyaminoalkyl groups to the pyrrolo[2,1-c][1,4]benzodiazepine pharmacophore in order to alter its characteristic DNA sequence binding preference. To this end S(N)Ar reactions of 2-nitro-5-fluorobenzoate
- Matsumoto, Kiyoshi,Iida, Hirokazu,Lown, J. William
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p. 1015 - 1020
(2007/10/03)
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- Conversion of Formamides to Alcohols via N-Nitrosation
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Secondary formamides were found to be favorable sources for the efficient oxygenation site via N-nitrosation.Thermal reaction (85 deg C in benzene) of N-nitrozo formamides proceeded effectively to provide the corresponding formates in good yields, which, then, were hydrolyzed to alcohols under weakly basic conditions.In treatment of optically active formamide, the corresponding alcohol was isolated with 72percent retention of configuration.
- Iwata, Masaaki,Kuzuhara, Hiroyoshi
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p. 1195 - 1198
(2007/10/02)
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