A mild and efficient chemoselective protection of amines as N-benzyloxycarbonyl derivatives in the presence of La(NO3)3·6H2O under solvent-free conditions
A facile and versatile method for the chemoselective N-benzyloxycarbonylation of amines has been developed by treatment with benzyloxycarbonyl chloride (Cbz-Cl) in the presence of lanthanum(III) nitrate hexahydrate under solvent-free conditions. The metho
The invention provides antiarrhythmic agents of the formula:- or a pharmaceuticaliy acceptable salt thereof, wherein R1 is C1-C4 alkyl; X is -(CH2)2-, -CH(OH)CH2-, -COCH2- or a direct link;
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(2008/06/13)
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