A facile synthesis of carvedilol, β-adrenergic blocking agent, via a key 5-substituted-.-oxazolidinone intermediate
A facile synthesis of Carvedilol via a key 5-substituted-.-oxazolidinone intermediate is described and this approach avoids the formation of bis side product (impurity B). This approach could be useful for the preparation of many β-amino alcohols without formation of bis impurity.
Madhusudhan,Kumar, B. Anand,Chintamani,Rao, M. Narasimha,Udaykiran,Suresh,Kumar, V. Kiran,Mukkanti
experimental part
p. 606 - 610
(2010/12/25)
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