- COMPOUND HAVING BENZO SEVEN-MEMBERED RING STRUCTURE, PREPARATION METHOD THEREFOR, AND USE THEREOF
-
The present invention relates to a compound having a benzo seven-membered ring structure, and a preparation method therefor, and use thereof. The compound has a structure as represented by formula (I). Provided is use of the compound having the structure and prepared with the preparation method of the present invention, enantiomers, diastereomers, racemates and mixtures thereof of the compound, as well as chemically acceptable salts, crystalline hydrates and solvent mixtures of the compound and the enantiomers, diastereomers, racemates and mixtures thereof of the compound in the preparation of drugs for treating BET Bromodomain BRD4 activity or expression level related diseases.
- -
-
Paragraph 0069-0070
(2021/12/14)
-
- One-Pot Synthesis of Spirocyclopenta[ a]indene Derivatives via a Cascade Ring Expansion and Intramolecular Friedel-Crafts-Type Cyclization
-
A one-pot efficient synthetic approach for the rapid construction of spirocyclopenta[a]indene derivatives has been developed via an iodine-initiated cascade ring expansion and intramolecular Friedel-Crafts-type cyclization from propargyl alcohol-tethered alkylidenecyclobutanes under mild conditions with broad substrate scope. This cascade process can be elegantly conducted on a gram scale. A plausible reaction mechanism has been proposed on the basis of a series of deuterium labeling and control experiments.
- Li, Quanzhe,Liu, Jiaxin,Wei, Yin,Shi, Min
-
p. 2438 - 2455
(2020/01/31)
-
- Domino Synthesis of Thioflavones and Thioflavothiones by Regioselective Ring Opening of Donor-Acceptor Cyclopropane Using In-Situ-Generated Thiolate Anions
-
A copper-catalyzed intramolecular ring opening of donor-acceptor cyclopropane is developed for the synthesis of 3-alkyl-carbonated thioflavones and further extended to 3-alkyl-carbonated thioflavothione, using xanthate as a sulfur surrogate. This reaction
- Sundaravelu, Nallappan,Sekar, Govindasamy
-
supporting information
p. 6648 - 6652
(2019/09/07)
-
- Palladium Nanoparticles-Catalyzed Synthesis of Indanone Derivatives via Intramolecular Reductive Heck Reaction
-
An efficient protocol for the straightforward, single-step synthesis of 3-aryl-1-indanones from 2′-iodochalcone via reductive Heck reaction using phosphine free, stable and reusable binaphthyl stabilized palladium nanoparticle (Pd-BNP) as a catalyst has been described. An immense array of substrate scope with electron-rich and deficient 2′-iodochalcones have been synthesized. Further derivatization of product indanones have been achieved successfully. The heterogeneous nature of the Pd-BNP has been validated by centrifugation test and mercury poisoning experiment. Pd-BNP has been successfully recycled up to 5 cycles without any significant loss in reaction yield and particle size of nanoparticles, confirmed by TEM analysis. (Figure presented.).
- Parveen, Naziya,Sekar, Govindasamy
-
p. 4581 - 4595
(2019/09/03)
-
- Palladium-Catalyzed Intermolecular Carbene Insertion Prior to Intramolecular Heck Cyclization: Synthesis of 2-Arylidene-3-aryl-1-indanones
-
A domino process that converges the migratory insertion of carbene with a Heck reaction has been established as a versatile tool for the synthesis of 2-arylidene-3-aryl-1-indanones from very stable and easily accessible N-tosylhydrazones and 2′-iodochalco
- Arunprasath, Dhanarajan,Muthupandi, Pandi,Sekar, Govindasamy
-
supporting information
p. 5448 - 5451
(2015/11/18)
-
- Copper-Catalyzed Domino Synthesis of 2-Arylthiochromanones through Concomitant C-S Bond Formations Using Xanthate as Sulfur Source
-
An efficient domino process for the synthesis of thioflavanones has been described using a copper catalyst without addition of any external ligand. A variety of thioflavanones have been synthesized from easily accessible 2′-iodochalcones or 2′-bromochalco
- Sangeetha, Subramani,Muthupandi, Pandi,Sekar, Govindasamy
-
supporting information
p. 6006 - 6009
(2016/01/09)
-
- Pd-catalyzed tandem homocoupling-aldol-dehydration of ortho-acylphenyl iodides
-
A Pd-catalyzed cascade Ullmann coupling-aldol-dehydration reaction of ortho-acylphenyl iodides has been explored. This transformation provides a concise access to colchino analogues in moderate to good yields with wide functional group tolerance.
- Fu, Meiqin,Lin, Dongen,Deng, Yuanfu,Zhang, Xiao-Qi,Liu, Yanchu,Lai, Chunsong,Zeng, Wei
-
p. 23595 - 23603
(2014/07/07)
-
- Concise synthesis of 1-naphthols under mild conditions through a copper-catalyzed arylation of methyl ketones
-
A concise synthesis of 1-naphthols via cyclization of o-iodoacetophenones and methyl ketones has been realized under very mild conditions. The cyclization process is initiated by a rare coppercatalyzed arylation of simple methyl ketones with ortho-iodoacetophenones.
- Lou, Zhenbang,Zhang, Shu,Chen, Chao,Pang, Xinlong,Li, Ming,Wen, Lirong
-
supporting information
p. 153 - 159
(2014/03/21)
-