- Synthesis of some 1-{2-(phthalimido-N-oxy)-ethyl} derivatives of 4-(4-substituted phenyl)-2,6-dimethyl-1,4-dihydro-3,5-bis-N-4-oxo-2- phenylquinazolin-3(4H)-ylcarboxamides
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A series of 1-{2-(phthalimido-N-oxy)-ethyl}-4-(4-substituted phenyl)-2,6-dimelhyl-1,4-dihydro-3,5-bis-N-(4-oxo-2-phenylquinazolin-3(4H) -ylcarboxamides (6a-d) have been synthesized via a multistep reaction sequence. Ethyl acetoacetate, various araldehydes and aminonia were condensed in ethanol to yield diethyl 4-(4-substituted phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5- dicarboxylate (2a-d). Ester group of these 2a-d was replaced by hydrazine hydrate in dioxane to give 4-(4-substituted phenyl)-2,6-dimethyl-1,4- dihydropyridine-3,5-dicarbohydrazide (3a-d). These were further treated with benzoxazine-4(3H)-one to give 4-(4-substituted phenyl)-2,6-dimethyl-1,4-dihydro- 3,5-bis-N-(4-oxo-2-phenylquinazolin-3(4H)-ylcarboxamides (4a-d). Final compounds 6a-d were obtained by refluxing 4a-d with bromoethoxyphthalimide (5). The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR and mass spectral data.
- Dangi, Raja Ram,Hussain, Nasir,Sain, Devendra Kumar,Talesara
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p. 1409 - 1414
(2011/09/20)
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