The direct syntheses of two potential anti-hypertensive drug candidates having the indole skeleton (2 and 3), using the β-cyano-aldehyde 6 or aγ-amide-aldehyde in Fischer condensations with p-methoxyphenylhydrazine are described.As by-products from these syntheses we isolated the chloropyrrole (11) and two diastereoisomeric molecules (12-E and 12-Z), one of them leading selectively to the N-acetylpyrrole 13.The structure and stereochemistry of three minor products (10, 12-E and 14) were confirmed by single crystal X-ray diffraction studies.
Zepeda, L. Gerardo,Rojas-Gardida, Mirna,Morales-Rios, Martha S.,Joseph-Nathan, Pedro
p. 6439 - 6448
(2007/10/02)
More Articles about upstream products of 126481-00-3
